A novel fiber chimeric conditionally replicative adenovirus-Ad5/F35 for tumor therapy
نویسندگان
چکیده
منابع مشابه
Generation of a novel, cyclooxygenase-2-targeted, interferon-expressing, conditionally replicative adenovirus for pancreatic cancer therapy.
BACKGROUND Oncolytic adenoviruses provide a promising alternative for cancer treatment. Recently, adjuvant interferon (IFN)-alfa has shown significant survival benefits for pancreatic cancer, yet was impeded by systemic toxicity. To circumvent these problems adenovirus with high-level targeted IFN-alfa expression can be generated. METHODS Conditionally replicative adenoviruses (CRAds) with im...
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ژورنال
عنوان ژورنال: Cancer Biology & Therapy
سال: 2017
ISSN: 1538-4047,1555-8576
DOI: 10.1080/15384047.2017.1395115